The Prognostic Significance of p16 in Patients with Locoregionally Advanced Head and Neck Cancer Treated with Concurrent 5-Fluorouracil, Hydroxyurea, Cetuximab, and IMRT
β Scribed by Lau, K.; Tong, C.C.L.; Rivera, M.; Packer, S.H.; Cannan, D.; Teng, M.S.; Sikora, A.G.; Gupta, V.; Genden, E.M.; Kao, J.
- Book ID
- 123429435
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 52 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0360-3016
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## Abstract ## Background Human papillomavirus (HPV)βrelated squamous cell cancer of the head and neck (SCCHN) has emerged as a distinct clinical entity. The expression of p16 protein can be used as a surrogate for HPV status. ## Methods p16 immunohistochemistry (IHC) was assessed in archival pa
## Abstract ## Background. In locally advanced head and neck cancer, concurrent chemoradiotherapy (CRT) with combined 5βfluorouracil (5βFU) and cisplatin has increased acute toxicities as well as survival. Onceβweekly chemotherapeutic administration schedule may reduce severe toxicities. Thus, we