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Prognostic significance of p16 in locally advanced squamous cell carcinoma of the head and neck treated with concurrent cisplatin and radiotherapy

✍ Scribed by Harold Y. Lau; Sony Brar; Alexander C. Klimowicz; Stephanie K. Petrillo; Desirée Hao; Nigel T. Brockton; Christina S. Kong; Susan P. Lees-Miller; Anthony M. Magliocco

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
328 KB
Volume
33
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background

Human papillomavirus (HPV)–related squamous cell cancer of the head and neck (SCCHN) has emerged as a distinct clinical entity. The expression of p16 protein can be used as a surrogate for HPV status.

Methods

p16 immunohistochemistry (IHC) was assessed in archival paraffin‐embedded material for 55 patients with locally advanced SCCHN treated with a uniform regimen of cisplatin and radiation. HPV status was assessed by colorimetric in situ hybridization (CISH) and polymerase chain reaction (PCR).

Results

Compared with p16‐ and HPV‐negative patients, the p16‐ and HPV‐positive patients had improved overall survival, disease‐free survival, and locoregional recurrence rates.

Conclusions

p16 IHC may serve as a useful surrogate and prognostic marker for patients with HPV‐related SCCHN treated with cisplatin and radiation. © 2010 Wiley Periodicals, Inc. Head Neck, 2011

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