Recently, technetium-99m (99mTc) labeling of proteins through the use of a bifunctional chelating agent (BCA) has been reported. In previous work, a BCA containing a di(N-methylthiosemicarbazone) (DTS) moiety for 99mTc has offered good potential; however, conjugation with bulky proteins has induced
โฆ LIBER โฆ
The production of 99mTc-labeled conjugated antibodies using a cyclam-based bifunctional chelating agent
โ Scribed by Franz, J.; Volkert, W.A.; Barefield, E.K.; Holmes, R.A.
- Book ID
- 123487123
- Publisher
- Elsevier Science
- Year
- 1987
- Weight
- 370 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0883-2897
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Background. The development of new bifunctional chelating agents for the labeling of monoclonal antibodies with radiometals is a desirable goal in the area of radioimmunodetection and radioimmunotherapy of cancer. The authors have developed a new N,S-ligand, N-(S-acetylmercaptoacetyl) (p-NCS)phenyla