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The production and modification of cytochrome P-450 difference spectra by in vivo administration of methylenedioxyphenyl compounds

โœ Scribed by R.M. Philpot; E. Hodgson


Book ID
113135285
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
568 KB
Volume
4
Category
Article
ISSN
0009-2797

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Eight methylenedioxyphenyl (MDP) compounds were examined for their ability to induce cytochrome P450 (P450) in mouse liver. Induction by safrole, isosafrole, and dihydrosafrole was studied in both C57BLl6N (Ah-responsive) and DBA/2N (Ahnonresponsive) male mice after IP administration of 200 mglkglda