A model is described for the repair of induced double-strand breaks in DNA which involves a proposed heteroduplex intermediate and normally occurring repair enzymes. The model predicts that this repair can lead to non-reciprocal and/or reciprocal recombination. The evidence which has been evaluated
✦ LIBER ✦
The processing of double-stranded DNA breaks for recombinational repair by helicase–nuclease complexes
✍ Scribed by Joseph T.P. Yeeles; Mark S. Dillingham
- Book ID
- 113568172
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 959 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1568-7864
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## Abstract Abnormal activation of cellular DNA repair pathways by deregulated signaling of receptor tyrosine kinase systems has broad implications for both cancer biology and treatment. Recent studies suggest a potential link between DNA repair and aberrant activation of the hepatocyte growth fact