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The presence of herpesvirus saimiri genomes in virus-transformed cells

✍ Scribed by Bernhard Fleckenstein; Ingrid Müller; Jürgen Werner

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
721 KB
Volume
19
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Herpesvirus saimiri (H. saimiri) ‐transformed cells contain both types of viral DNA, unique L‐DNA and highly repetitive H‐DNA. DNA from spleen and lymph‐node autopsies of two tumor‐bearing marmoset monkeys contained 0.14–0.75 / viral L‐DNA and 0.115–1.08 / H‐DNA. This amount of H‐DNA would be equivalent to the presence of 14–130 M‐genomes per diploid tumor tissue cell. Six virus‐transformed lymphoid cell lines, two of them virus‐producing, contained 0.69–2.27 / H‐DNA and more than 0.72–1.95 / L‐DNA. These concentrations of H‐DNA sequences correspond to 83–274 M‐genome copies per lymphoid tissue culture cell. The majority of viral genomes in transformed non‐producer lymphoid cell lines appeared to be defective, since part of the L‐sequences present in virions were found to be deleted in the genome copies of transformed cells. There was a relative excess of repetitive H‐sequences in all transformed cells in regard to the ratio of H‐DNA/L‐DNA in M‐genomes of H. saimiri virions.

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