Detection of Epstein–Barr virus and human herpesvirus 7 and 8 genomes in primary cutaneous T- and B-cell lymphomas

✍ Scribed by E. Nagore; E. Ledesma; C. Collado; V. Oliver; A. Pérez-Pérez; A. Aliaga

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 225 KB
• Volume: 143
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2000.03657.x

✦ Synopsis

Background:

Several studies have investigated the possible involvement of viral agents, particularly herpesviruses, in primary cutaneous lymphoma (pcl).

Objectives:

Our aim was to screen for the presence of human herpesvirus 7 (hhv-7) and 8 (hhv-8) genomes in samples of pcl, and to determine if their presence was independent of epstein-barr virus (ebv).

Methods:

Screening was performed using polymerase chain reaction assay in 64 skin samples from historical lesional tissues with pcl.

Results:

Only nine cases showed positivity for hhv-7: four of 29 mycosis fungoides (mf), two of four cd30-positive large-cell cutaneous t-cell lymphoma (ctcl), two of 12 follicle centre cutaneous b-cell lymphoma (cbcl) and one of nine marginal zone cbcl. fifteen cases tested positive for ebv: seven of 29 mf, two of four pleomorphic small/medium sized ctcl, three of three angiocentric ctcl, one of 12 follicle centre cbcl and two of nine marginal zone cbcl. all cases were uniformly negative for hhv-8. no simultaneous positivity was found for ebv and hhv-7. controls tested negative for all viruses.

Conclusions:

The findings indicate that ebv, hhv-7 and hhv-8 seem not to be involved in the pathogenesis of pcl.