The dopamine D-1 receptor antagonist, SCH 23390 ((R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3- benzazepin-7-ol), was labelled by alkylation of the desmethyl compound SCH 24518 ((R)-(+)-8-chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7- ol) with [11C]methyl iodide. A multivariate o
The preparation of11C-labelled fluoromethane for the study of regional cerebral blood flow using positron emission tomography
✍ Scribed by Sharon Stone-Elander; Per Roland; Lars Eriksson; Jan-Eric Litton; Peter Johnström; Lennart Widen
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 409 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0340-6997
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Carbon-l l-labelled glycine has been prepared by a Bficherer-Strecker synthesis using [tiC]cyanide, formaldehyde and ammonium carbonate. Total synthesis time, including chromatographic purification, was 30-35 min from end-of-bombardment. Radiochemical yield was 35%, based on ["C]cyanide and radioche