𝔖 Bobbio Scriptorium
✦   LIBER   ✦

11C-labelled glycine: Synthesis and preliminary report on its use in the investigation of intracranial tumours using positron emission tomography

✍ Scribed by Peter Johnström; Sharon Stone-Elander; Kaj Ericson; Mikael Mosskin; Mats Bergström

Publisher
Elsevier Science
Year
1987
Weight
740 KB
Volume
38
Category
Article
ISSN
0883-2889

No coin nor oath required. For personal study only.

✦ Synopsis

Carbon-l l-labelled glycine has been prepared by a Bficherer-Strecker synthesis using [tiC]cyanide, formaldehyde and ammonium carbonate. Total synthesis time, including chromatographic purification, was 30-35 min from end-of-bombardment. Radiochemical yield was 35%, based on ["C]cyanide and radiochemical purity was shown to be > 98% by analytical HPLC. The UC-labelled glycine thus prepared was used along with [~Ga]EDTA and r-[methyl-~C]methionine in the visualization of an anaplastic astrocytoma by positron emission tomography.

📜 SIMILAR VOLUMES

Synthesis of radiotracers for studying m
Synthesis of radiotracers for studying muscarinic cholinergic receptors in the living human brain using positron emission tomography: [11C]dexetimide and [11C]levetimide
✍ Robert F. Dannals; Bengt Långström; Hayden T. Ravert; Alan A. Wilson; Henry N. W 📂 Article 📅 1988 🏛 Elsevier Science ⚖ 298 KB

Dexetimide (Fig. la), a potent muscarinic cholinergic receptor antagonist, and levetimide (Fig. lb), its pharmacologically inactive enantiomer, were labeled with "C for non-invasive in vivo studies of muscarinic cholinergic receptors in the human brain using positron emission tomography. The synthes

A proposed method for the determination
A proposed method for the determination of cerebral regional intermediary glucose metabolism in humans in vivo using specifically labeled 11C-glucose and positron emission transverse tomography (PETT). I. An animal model with 14C-glucose and rat brain autoradiography
✍ Dr. William Sacks; Shirley Sacks; Anthony Badalmenti; Arthur Fleischer 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 834 KB

## Abstract Based upon data obtained with our arterio‐venous technique for the determination of cerebral metabolism in humans in vivo we have proposed a method for the determination of cerebral regional intermediary glucose metabolism in humans in vivo using specifically labeled ^11^C‐glucose and p