The Preparation of α-(Dialkylaminoalkyl)-acenaphthene-methanols 1

✍ Scribed by Nightingale, Dorothy; Ungnade, H. E.; French, H. E.

• Book ID: 121324186
• Publisher: American Chemical Society
• Year: 1945
• Tongue: English
• Weight: 383 KB
• Volume: 67
• Category: Article
• ISSN: 0002-7863
• DOI: 10.1021/ja01224a012

✦ Synopsis

A portion of the above picrate was treated with an excess of 6 N HCl, and the precipitated picric acid was filtered off. The acid filtrate was extracted with ether to remove traces of picric acid. The aqueous layer was chilled in ice, and enough sodium hydroxide wa5 added to rnakc the mixture just alkaline. The white precipitate, filtered o f f a:d crystallized from 40;; ethanol, melted a t 117.&117.8° fyield G.3 g.). The melting point and analytical result agree Ivith those of the myosmine benzoylation product which Spiith, Wenusch and Zajic3 reported to be 3-pyridyl-w-benzamidopropyl ketone. The picrate of this base melted a t 151,& 152.0'. When mixed with the picrate of S-henzoylmyosmine, the melting point was depressed.