𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The preparation of tritiated E- and Z-4-aminobut-2-enoic acids, conformationally restricted analogues of the inhibitory neurotransmitter 4-aminobutanoic acid (GABA)

✍ Scribed by Rujee K. Duke; Robin D. Allan; Colleen A. Drew; Graham A. R. Johnston; Kenneth N. Mewett; Mervyn A. Long; Chit Than

Book ID
102901479
Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
626 KB
Volume
33
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A synthesis of [^3^H]E‐ and [^3^H]Z‐4‐aminobut‐2‐enoic acids from methyl 4‐N‐phthalimidobut‐2‐ynoate by catalytic hydrogenation using tritium gas in the presence of a homogeneous catalyst, tris(triphenylphosphine)rhodium(I) chloride, is reported. HPLC separation of the E‐ and Z‐isomers, and the saturated analogue, 4‐aminobutanoic acid (GABA), is also described.

📜 SIMILAR VOLUMES

ChemInform Abstract: Syntheses of Novel
ChemInform Abstract: Syntheses of Novel Piperidin-4-ylphosphinic Acid, and Piperidin-4-ylphosphonic Acid Analogues of the Inhibitory Neurotransmitter 4-Aminobutyric Acid (GABA).
✍ J. KEHLER; B. EBERT; O. DAHL; P. KROGSGAARD-LARSEN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

Syntheses of Novel Piperidin-4-ylphosphinic Acid, and Piperidin-4-ylphosphonic Acid Analogues of the Inhibitory Neurotransmitter 4-Aminobutyric Acid (GABA). -The novel acids (V)-(VIII) are synthesized utilizing a sequential Pudovik addition followed by a modified Barton deoxygenation and acidic hydr

Effects of the conformationally restrict
Effects of the conformationally restricted GABA analogues, Cis-and Trans-4-aminocrotonic acid, on GABA neurotransmission in primary neuronal cultures
✍ Carmen Vale; M. Teresa Vilaró; Eduardo Rodríguez-Farré; Cristina Suñol 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 217 KB 👁 2 views

The effects of the GABA analogues, cis-and trans-4aminocrotonic acid (ACA) on GABA A receptor function and GABA uptake, together with the presence of -1 subunit mRNA and putative GABA C receptors, were studied in primary cultures of neocortical neurons and cerebellar granule cells. Both isomers indu