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The Preparation of Some Substituted Thiohydantoins and Thioimidazoles

✍ Scribed by Jackman, Mary; Klenk, Mabel; Fishburn, B.; Tullar, B. F.; Archer, S.


Book ID
126882504
Publisher
American Chemical Society
Year
1948
Tongue
English
Weight
366 KB
Volume
70
Category
Article
ISSN
0002-7863

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A New and Convenient Synthesis of Some Substituted Thiohydantoins. -3-Substituted thiohydantoins (III) (7 examples) are synthesized in satisfactory yields by base-mediated reaction of thioureas (I) with chloroacetyl chloride (II). The thiohydantoins smoothly undergo S-alkylation [β†’(V)]. -