The preparation of n-disubstituted formamides
β Scribed by M.B. Frankel; H. Feuer; J. Bank
- Publisher
- Elsevier Science
- Year
- 1959
- Tongue
- French
- Weight
- 113 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Although organometallic compounds are known to react with carboxamides to yield ketones [l]. N,N-disubstituted carbamates (DSC) have not previously been used for their preparation. Thus, interaction-of two equivalents of an organometallic compound with one equivalent of DSC (0.5 -3 hours at -70' to
C 2 -Symmetric 1,2-diamines are useful precursors to numerous reagents used in asymmetric synthesis and catalysis. We report here an efficient protocol for converting the two most commonly used trans-1,2-diamines to N,N-disubstituted derivatives, a transformation that simplifies the preparation of n