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An efficient method for the preparation of N,N-disubstituted 1,2-diamines

✍ Scribed by Judith M Mitchell; Nathaniel S Finney

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
62 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

C 2 -Symmetric 1,2-diamines are useful precursors to numerous reagents used in asymmetric synthesis and catalysis. We report here an efficient protocol for converting the two most commonly used trans-1,2-diamines to N,N-disubstituted derivatives, a transformation that simplifies the preparation of non-C 2 -symmetric diamines. Central to the method is the high-yielding conversion of the diamines to the corresponding monoacetylated derivatives via imidazoline intermediates.

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ChemInform Abstract: An Efficient Method
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