ChemInform Abstract: A Practical and Efficient Synthesis of Chiral N,N-Disubstituted C2 Symmetric Diamines Derived from (R,R)-1,2-Diaminocyclohexane.
β Scribed by Alexandre Alexakis; Anne-Sophie Chauvin; Ricardo Stouvenel; Emmanuel Vrancken; Stephane Mutti; Pierre Mangeney
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 30 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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A Convenient Access to N,N-Disubstituted Amides Derived from (1R,3S)-(-)-2,2-Dimethyl-3-formylcyclopropane-1-carboxylic Acid. -The enantiopure title amides are obtained in three steps from biocartol (I). Deprotection of the mono-N-substituted amides did not give the expected aldehydes such as (VII)
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