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The preparation and the nucleophilic reaction of 3,3-di(1-azolyl)-2-alken-1-ones, precursor of acetylketene derivatives

โœ Scribed by Choji Kashima; Tadakuni Tajima; And Yoshimori Omote


Book ID
112127349
Publisher
Journal of Heterocyclic Chemistry
Year
1984
Tongue
English
Weight
356 KB
Volume
21
Category
Article
ISSN
0022-152X

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Hydroxy-1-phenylthio-2-alkynes (5) reacted with dihydropyran to afford the corresponding 4-tetrahydropyranyloxy derivatives which, on treatment with KHMDS, gave a mixture of (E)-and (Z)-1-phenylthio-3-alken-1-ynes, with the former predominant. When MeLi was used in the place of KHMDS, the (Z)-isomer