β Scribed by Butler, C.L. ;Cretcher, Leonard H.
No coin nor oath required. For personal study only.
Quinidine is separated from the mixture of alkaloids extracted from cinchona bark after removal of q ~i n i n e . ~ Since the hydrogenated derivatives of the four common cinchona alkaloids, quinine, quinidine, cinchonine and cinchonidine, also occur naturally, and since the solubilities of the reduced bases are quite similar to those of the unreduced substances, the preparation of absolutely pure alkaloids is sometimes exceedingly difficult. It is not surprising that ordinary commercial grades should be contaminated. Dawson4 has listed the impurities which may be found in U. S. P. or B. P. grades of the common cinchona alkaloids. These are shown in Table I, and it will be noticed that the amount of impurity in ordinary quinidine may be quite large. TABLE I.-POSSIBLE IMPURITIES I N u. s. P. OR B. P. CINCHONA ALKALOIDS.
π SIMILAR VOLUMES
poses, and the treatment. bination of sodium nitrite and sodium thiosulphate. a case of cyanide poisoning should be managed are given.