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The Preclinical and Clinical Pharmacology of SK&F 104353, a Potent and Selective Peptidoleukotriene Receptor Antagonist

✍ Scribed by T. J. TORPHY; I. FAIFERMAN; J. G. GLEASON; R. F. HALL; M. A. LEWIS; C. BROOM; H. M. HELFRICH; J. F. NEWTON; D. W. P. HAY

Book ID
119866564
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
765 KB
Volume
629
Category
Article
ISSN
0890-6564

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SK&F 104353, a selective leukotriene rec
SK&F 104353, a selective leukotriene receptor antagonist, inhibits leukotriene D4- and antigen-induced bronchoconstriction in cynomolgus monkeys
✍ R.R. Osborn; D.W.P. Hay; M.A. Wasserman; T.J. Torphy πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier 🌐 English βš– 444 KB

The ability of SK&F 104353 to prevent and reverse leukotriene (LT) D4- and antigen (Ag)-induced bronchoconstriction was examined in anesthetized, spontaneously breathing cynomolgus monkeys. Aerosol administration of LTD4 (10 micrograms/ml; 20 breaths) produced a sustained increase in pulmonary resis