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Effect of the Leukotriene Receptor Antagonist, SK&F 104353, on the Sequelae of Endotoxemia in Conscious Rats

✍ Scribed by E. F. SMITH III; L. B. KINTER; M. JUGUS; R. D. ECKARDT; J. F. NEWTON


Book ID
119862048
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
126 KB
Volume
524
Category
Article
ISSN
0890-6564

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The effect of aerosolized SK&F 104353-Z2
✍ G.F. Joos; J.C. Kips; R.A. Pauwels; M.E. Van Der Straeten πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier 🌐 English βš– 494 KB

Leukotriene D4 (LTD4) is a potent bronchoconstrictor and vasoactive mediator that has been implicated in the pathogenesis of bronchial asthma. We have studied the effect of SK&F 104353-Z2, a specific LTD4 antagonist, on LTD4-induced bronchoconstriction in asthmatics. A total of 12 mild asthmatics (m