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The Polyether Bistratene A Activates Protein Kinase C–δ and Induces Growth Arrest in HL60 Cells

✍ Scribed by Gareth Griffiths; Bernadette Garrone; Elizabeth Deacon; Penelope Owen; Judit Pongracz; Graham Mead; Arthur Bradwell; Dianne Watters; Janet Lord


Book ID
115578535
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
631 KB
Volume
222
Category
Article
ISSN
0006-291X

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The four fluorescent derivatives of TPA-dansylaza-TPA, NBDaza-TPA, and (N)and (P)-dansylamino-TPA-were synthesized and examined for their ability to induce differentiation in human promyelocytic leukemic HL60 cells. At a concentration of 20 nM, all the derivatives inhibited proliferation and induced