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The ability of diterpene esters with selective biological effects to activate protein kinase C and induce HL-60 cell differentiation

✍ Scribed by A.Tudor Evans; Colin McPhee; Fatima Beg; Fred J. Evans; Alastair Aitken


Book ID
115781095
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
373 KB
Volume
38
Category
Article
ISSN
0006-2952

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Effects of fluorescent derivatives of TP
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The four fluorescent derivatives of TPA-dansylaza-TPA, NBDaza-TPA, and (N)and (P)-dansylamino-TPA-were synthesized and examined for their ability to induce differentiation in human promyelocytic leukemic HL60 cells. At a concentration of 20 nM, all the derivatives inhibited proliferation and induced