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The poeumotoxicity of 7-glutathionyldehydronetronecine, a possible metabolite of the pyrrolizidine alkaloid, monocrotaline

✍ Scribed by R.J. Huxtable; R. Bowers; M. Michnicka; W.M. Lafranconi


Book ID
115883835
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
122 KB
Volume
183
Category
Article
ISSN
0014-2999

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Alkylation of nucleosides by dehydromono
✍ Haruki Niwa; Takeshi Ogawa; Osamu Okamoto; Kiyoyuki Yamada πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 French βš– 265 KB

## Reaction of dehydmmonocrotaline (3), the putative toxic metabolite of the carcinogenic pyrrolizidinc alkaloid monoerotahne (Z), with various nucleosides proceeded mostly at the C-9" position of 3 to give several nitrogen atom-alkylated nucleosides including N-7 alkylated 2'deoxyguanosine 14. P