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The Plasma Membrane Ca2+-ATPase in Spontaneously Hypertensive Rats

โœ Scribed by BASIL D. ROUFOGALIS; SHI CHEN; ELEANOR P. W. KABLE; TUAN H. KUO; G. R. MONTEITH


Book ID
111393555
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
186 KB
Volume
834
Category
Article
ISSN
0890-6564

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The purified Ca2+/Mg2+ ATPase from rat heart plasma membrane was activated by Ca2+ and Mg2+ with Ka values of 1.47 mM and 2.51 mM, respectively; other divalent cations also activated the enzyme but to a lesser extent. Divalent cations like Cu2+, Zn2+, Ni2+, Cd2+ were potent inhibitors of the enzyme