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The Phase II/III Transition: Toward the Proof of Efficacy in Cancer Clinical Trials

✍ Scribed by Melissa Fazzari; Glenn Heller; Howard I Scher

Book ID
114186746
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
118 KB
Volume
21
Category
Article
ISSN
0197-2456

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Phase I Clinical Trials in children with cancer are carried out with therapeutic intent, so as to define antileukemic/antitumor activity, dose-limiting toxicity, maximum tolerated dosage, and pharmacokinetics. These studies define a dosage of an agent or combination that may be used in a larger stud