๐”– Bobbio Scriptorium
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The conduct of phase I-II clinical trials in children with cancer

โœ Scribed by Pratt, Charles B.

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
677 KB
Volume
19
Category
Article
ISSN
0098-1532

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โœฆ Synopsis

Phase I Clinical Trials in children with cancer are carried out with therapeutic intent, so as to define antileukemic/antitumor activity, dose-limiting toxicity, maximum tolerated dosage, and pharmacokinetics. These studies define a dosage of an agent or combination that may be used in a larger study of pediatric patients with leukemias or malignant solid tumors. The content of phase I and II protocols is outlined, with a brief discussion of the ethics of performance of phase I trials in children.

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