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The Pharmacology and Metabolism of the Thiopurine Drugs 6-Mercaptopurine and Azathioprine

✍ Scribed by Van Scoik, Kurt G.; Johnson, Curtis A.; Porter, William R.

Book ID
115518833
Publisher
Informa plc
Year
1985
Tongue
English
Weight
784 KB
Volume
16
Category
Article
ISSN
0360-2532

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Azathioprine toxicity, 6-mercaptopurine
Azathioprine toxicity, 6-mercaptopurine accumulation and the β€œpoor” 6-thiopurine methylator phenotype
✍ A. Escousse; C. Sgro; G. Rifle; C. Mousson; G. Zanetta; D. Chevet πŸ“‚ Article πŸ“… 1995 πŸ› Springer 🌐 English βš– 152 KB

The therapeutic use of the immunosuppressive drug Azathioprine (AZA) in preventing rejection in allograft transplant recipients is limited by its haematological toxicity, mainly leukopenia. AZA is a "prodrug", spontaneously converted in the body to two derivatives, 6 mercaptopurine (6MP), and a nit