Azathioprine toxicity, 6-mercaptopurine
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A. Escousse; C. Sgro; G. Rifle; C. Mousson; G. Zanetta; D. Chevet
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Article
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1995
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Springer
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English
β 152 KB
The therapeutic use of the immunosuppressive drug Azathioprine (AZA) in preventing rejection in allograft transplant recipients is limited by its haematological toxicity, mainly leukopenia. AZA is a "prodrug", spontaneously converted in the body to two derivatives, 6 mercaptopurine (6MP), and a nit