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The pharmacokinetics of tiopronin as such is unknown

✍ Scribed by M. S. Carlsson; T. Denneberg; B. -M. Emanuelsson; B. K»gedal; S. Lindgren

Publisher
Springer
Year
1994
Tongue
English
Weight
210 KB
Volume
46
Category
Article
ISSN
0031-6970

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✦ Synopsis

The lack of investigation of the chemical binding of tiopronin to other compounds has hampered our understanding of the drug. From analytical studies [1, 2, 3], however, and from comparison with other thiols it can be deduced that in biological fluids several molecular species of tiopronin will be found including a) tiopronin as a free thiol (T-SH), the administered form, b)tiopronin as a symmetrical disulphide (T-S-S-T), or as mixed disulphide (T-S-S-R) with another low-molecular thiols (R-SH), such as cysteine and glutathione, and c) tiopronin as mixed disulphide with proteins (T-S-S-P) bearing a free thiolgroup.

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