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The pharmacokinetics of nifurtimox in chronic renal failure

✍ Scribed by G. González-Martin; S. Thambo; C. Paulos; I. Vásquez; J. Paredes

Publisher
Springer
Year
1992
Tongue
English
Weight
302 KB
Volume
42
Category
Article
ISSN
0031-6970

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✦ Synopsis

The pharmacokinetics of nifurtimox, a drug used in the treatment of Trypanosoma cruzi infections, has been studied in seven patients with chronic renal failure undergoing haemodialysis, and in seven healthy subjects. Each subject took nifurtimox 15 mg.kg-1 orally and blood samples were obtained for 10 h after administration. Nifurtimox in serum was analyzed by HPLC. The patients with chronic renal failure had a higher Cmax than the control subjects due to a change in systemic availability. An alternative explanation would be that both the distribution volume and the clearance had changed. The mean half-life in the patients with chronic renal failure was similar to that in the healthy subjects.

📜 SIMILAR VOLUMES

Pharmacokinetics of quinine in patients
Pharmacokinetics of quinine in patients with chronic renal failure
✍ P. Rimchala; J. Karbwang; K. Sukontason; V. Banmairuroi; P. Molunto; K. Na-Bangc 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 521 KB

Methods: We investigated the pharmacokinetics of quinine (Qn) following administration of a single oral dose of 600 mg Qn sulphate in six male Thai patients with a moderate degree of chronic renal failure (CRF), and six male Thai subjects with normal renal function. ## Results: The drug was well