Pharmacokinetics of diltiazem in severe renal failure
✍ Scribed by N. Pozet; J. L. Brazier; A. Hadj Aïssa; D. Khenfer; G. Faucon; E. Apoil; J. Traeger
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 263 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0031-6970
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The pharmacokinetics of oral diltiazem were studied in 10 patients with chronic renal failure not requiring dialysis and in five healthy volunteers after a single dose of 120mg. We found that patients with chronic renal failure had lower amounts of unchanged diltiazem and of its main metabolite (MA)
The plasma concentrations of quinine and its main metabolite, 3-hydroxyquinine (30HQn), were measured in 5 adult Thai patients with severe Plasmodium falciparum malaria and acute renal failure. Two patients required peritoneal dialysis but all survived. During acute renal failure plasma concentratio