✦ LIBER ✦

The pH and temperature dependence of the interaction of steroid hormones with the transport system of glucose in human erythrocytes

✍ Scribed by L. Lacko; B. Wittke; I. Lacko

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 426 KB
Volume: 90
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040900203

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✦ Synopsis

Abstract

The thermodynamic parameters ΔH°, ΔF°, ΔS° and the pH dependence of the interaction between steroids and the glucose carrier in human erythrocytes have been studied. The results indicate that, according to the structure of the steroids, hydrophilic as well as hydrophobic bonds can be involved in the association. For the binding of the C‐21‐steroids to the carrier the polarity rule has been observed to be valid. On the basis of the thermodynamic parameters it has been found that in the association process of the steroids with the carrier, simultaneous randomization of ordered water molecules is important.

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