The penetration of drugs into the lesions of spinal tuberculosis

✍ Scribed by K. Kumar

• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 141 KB
• Volume: 16
• Category: Article
• ISSN: 0341-2695
• DOI: 10.1007/bf00182989

✦ Synopsis

The concentration of antituberculous drugs in blood and pus from tuberculous spinal lesions was measured initially, and again after 3 to 5 months of treatment in 4 cases. The pre-and postchemotherapy drug concentrations were almost the same. This indicated that healing does not interfere with the penetration of the drugs into the lesion.

R6sum6. Les concentrations des drogues antituberculeuses au niveau mOme des ldsions ostdo-articulaires ont 6t6 mesur~es chez quatre malades aprbs 3 ~ 5 mois de chimioth6rapie sp~cifique. On a constat6 que les concentrations dans le sang et dans le pus tuberculeux ~taient pratiquement les m6mes avant et aprbs chimiothdrapie, sans difference significative (test de Wilcoxon: p >0.5). Ceci d6montre que la gu6rison des ldsions tuberculeuses par la chimiothdrapie sp6cifique n'influence pas la p6ndtration de ces drogues dans les rdgions ostdo-articulaires atteintes.