The pathogenesis of autoimmune diabetes mellitus
โ Scribed by A.A. Rossini; J.P. Mordes; D.L. Greiner
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 881 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
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Insulin dependent diabetes mellitus is a T-cell mediated autoimmune disease. Several &cell antigens, mostly non-tissue-specific, have been implicated in the disease process. The antigens and the autoimmune T cells exist in healthy individuals, as do many of the genes required for the development of
Correlation studies between cytokines expressed in islets and autoimmune diabetes development in NOD mice and BB rats have demonstrated that โค-cell destructive insulitis is associated with increased expression of proinflammatory cytokines (IL-1, TNFโฃ, and IFNโฃ) and type 1 cytokines (IFNโฅ, TNFโค, IL-2