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The pathogenesis and management of the coagulopathy of acute promyelocytic leukaemia

โœ Scribed by Karen A. Breen; David Grimwade; Beverley J. Hunt


Book ID
108677488
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
307 KB
Volume
156
Category
Article
ISSN
0007-1048

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The molecular pathogenesis of acute prom
โœ Anita R Mistry; Eva W Pedersen; Ellen Solomon; David Grimwade ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 815 KB

Acute promyelocytic leukaemia (APL) is characterised by chromosomal rearrangements of 17q21, leading to fusion of the gene encoding retinoic acid receptor alpha (RARalpha) to a number of alternative partner genes (X), the most frequent of which are PML (>95%), PLZF (0.8%) and NPM (0.5%). Over the la