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Pathogenesis and management of the bleeding diathesis in acute promyelocytic leukaemia

โœ Scribed by Anna Falanga; Frederick R Rickles

Book ID
119614382
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
240 KB
Volume
16
Category
Article
ISSN
1521-6926

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The molecular pathogenesis of acute prom
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โœ Anita R Mistry; Eva W Pedersen; Ellen Solomon; David Grimwade ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 815 KB

Acute promyelocytic leukaemia (APL) is characterised by chromosomal rearrangements of 17q21, leading to fusion of the gene encoding retinoic acid receptor alpha (RARalpha) to a number of alternative partner genes (X), the most frequent of which are PML (>95%), PLZF (0.8%) and NPM (0.5%). Over the la