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The p75NTR tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells

✍ Scribed by Fatima Khwaja; Arshia Tabassum; Jeff Allen; Daniel Djakiew


Book ID
116292268
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
444 KB
Volume
341
Category
Article
ISSN
0006-291X

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## Abstract p75^NTR^ was identified as a tumor and metastasis suppressor that functions in part __via__ induction of apoptosis in tumor cells. To examine p75^NTR^‐dependent apoptosis in tumor cells, we demonstrated that a dose‐dependent increase in p75^NTR^ expression was associated with a concomit

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## Abstract The neurotrophin (NTR) receptor (p75^NTR^) is a cell‐surface glycoprotein that binds to the neurotrophin family of growth factors, of which the prototypic member is nerve growth factor (NGF). This receptor was previously shown to retard cell‐cycle progression by inducing accumulation of