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Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein

✍ Scribed by Jocelyn C. Hsu; Anurupa Dev; Aimee Wing; Christine T. Brew; Leonard F. Bjeldanes; Gary L. Firestone


Book ID
113488096
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
622 KB
Volume
72
Category
Article
ISSN
0006-2952

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Indole-3-carbinol activates the ATM sign
✍ Christine T. Brew; Ida Aronchik; Jocelyn C. Hsu; Joon-Ho Sheen; Robert B. Dickso 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 968 KB

## Abstract The phytochemical indole‐3‐carbinol (I3C), from cruciferous vegetables such as broccoli, has been shown to elicit a potent anti‐proliferative response in human breast cancer cell lines. Treatment of the immortalized human mammary epithelial cell line MCF10A with I3C induced a G1 cell cy