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The p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis


Book ID
123035561
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
181 KB
Volume
11
Category
Article
ISSN
0169-5002

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The tumor-suppressor gene product p53 is clearly a component in several biochemical pathways, including transcription, DNA repair, genomic stability, cell-cycle control and apoptosis, that are central to human carcinogenesis. The p53 is functionally inactivated by mutational, viral, and cellular mec