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p53 mutational spectrum in human cancers: clues to cancer etiology and molecular pathogenesis


Book ID
122452018
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
276 KB
Volume
10
Category
Article
ISSN
0169-5002

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The p53 tumour suppressor gene is at the crossroads of a network of cellular pathways including cell cycle checkpoints, DNA repair, chromosomal segregation, and apoptosis. These pathways have evolved to maintain the stability of the genome during cellular stress from DNA damage, hypoxia, and activat