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The p53 Tumor Suppressor Gene and Nuclear Protein: Basic Science Review and Relevance in the Management of Bladder Cancer

✍ Scribed by SMITH, NORM D.; RUBENSTEIN, JONATHAN N.; EGGENER, SCOTT E.; KOZLOWSKI, JAMES M.

Book ID: 120006360
Publisher: Lippincott Williams and Wilkins
Year: 2003
Tongue: English
Weight: 158 KB
Volume: 169
Category: Article
ISSN: 0022-5347
DOI: 10.1097/01.ju.0000056085.58221.80

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## Abstract To investigate the importance of oncogenes and tumor suppressor genes in bladder carcinogenesis, we determined the status of the expression of the __MDM‐2__ and __p53__ genes and genetic alterations in the __p53__ gene in five bladder carcinoma cell lines and one kidney urothelial carci