The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer
β Scribed by Marianne Farnebo; Vladimir J.N. Bykov; Klas G. Wiman
- Book ID
- 116299984
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 280 KB
- Volume
- 396
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Loss of heterozygosity (LOH) on the short arm of chromosome 8 occurs at high frequencies in many tumor types, including colorectal carcinoma. We have previously used microcellβmediated chromosome transfer (MMCT) to map an approximately 7.7 Mb colorectal cancer suppressor region (CRCSR)
## Abstract The p53 tumor suppressor gene, which is frequently mutated in a wide variety of tumors, plays an important role in maintaining genomic integrity. Following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequenceβspecific transcription factor that regula