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The p53 network: cellular and systemic DNA damage responses in aging and cancer

✍ Scribed by H. Christian Reinhardt; Björn Schumacher


Book ID
113933203
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
383 KB
Volume
28
Category
Article
ISSN
0168-9525

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Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage, transduce the signal, and ultimately delay the cell cycle or trigger apoptosis. Recently, we have shown that BTG2/TIS21 gene expression was indu