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p53 suppression overwhelms DNA polymerase η deficiency in determining the cellular UV DNA damage response

✍ Scribed by Rebecca R. Laposa; Luzviminda Feeney; Eileen Crowley; Sebastien de Feraudy; James E. Cleaver

Book ID
113567887
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
990 KB
Volume
6
Category
Article
ISSN
1568-7864

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Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage, transduce the signal, and ultimately delay the cell cycle or trigger apoptosis. Recently, we have shown that BTG2/TIS21 gene expression was indu