The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo
✍ Scribed by Yang, Zhi-Yong; Perkins, Neil D.; Ohno, Takeshi; Nabel, Elizabeth G.; Nabel, Gary J.
- Book ID
- 109931613
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 889 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1078-8956
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The p21 protein is a universal inhibitor of cyclindependent kinases and of cell-cycle progression and is involved in numerous growth-inhibitory pathways in cell culture systems. Recent studies suggest that p21 regulates hepatocyte cell cycle progression in models of liver regeneration. The present s
## Abstract p21, a universal inhibitor of mammalian cyclin‐dependent kinases (CDK), regulates cell cycle progression by forming various distinct protein complexes with cyclins, CDKs, and the proliferating cell nuclear antigen. We have overexpressed recombinant human p21 in __E. coli__ and purified