Oxidative stress contributes to the cascade leading to dopamine cell degeneration in Parkinson's disease (PD). However, oxidative stress is intimately linked to other components of the degenerative process, such as mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity and inflammation. It
The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
β Scribed by Dr Stanley Fahn; Gerald Cohen
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 961 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0364-5134
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## Abstract Oxidative stress is well documented in Parkinson's disease (PD) and has been attributed to dopamine oxidative metabolism. However, evidence of oxidative stress is found in a variety of neurodegenerative disorders, suggesting that more general factors are responsible or that cytodestruct
Several links exist between the two mechanisms of neuronal degeneration (i.e., oxygen radical production and mitochondrial damage) proposed to have a role in Parkinson's disease. Indeed, mitochondria are critical targets for the toxic injury induced by oxygen radicals, and experimental evidence sugg
## Abstract Oxidative stress is influenced by the thiol homeostasis, which determines the redox milieu. One of its components is Cysteinylβglycine (CysβGly) generation, as its metabolic precursor is the free radicals scavenging glutathione. Levodopa is under suspicion to promote oxidative stress vi