✦ LIBER ✦

Challenging conventional wisdom: The etiologic role of dopamine oxidative stress in Parkinson's disease

✍ Scribed by J. Eric Ahlskog

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 113 KB
Volume: 20
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20362

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✦ Synopsis

Abstract

Oxidative stress is well documented in Parkinson's disease (PD) and has been attributed to dopamine oxidative metabolism. However, evidence of oxidative stress is found in a variety of neurodegenerative disorders, suggesting that more general factors are responsible or that cytodestructive processes secondarily generate oxyradical products. Increasing evidence points away from dopamine metabolism as an important contributor to PD neurodegeneration. Predictions from the dopamine oxidative stress hypothesis of PD reveal multiple inconsistencies. Although the clinical and therapeutic importance of the nigrostriatal dopaminergic system is undeniable, PD neuropathology is much more widespread. © 2004 Movement Disorder Society

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