Ninety percent of the world's youth live in Africa, Latin America and the developing countries of Asia. Despite this, the field of Youth Studies, like many others, is dominated by the knowledge economy of the Global North. To address these geo-political inequalities of knowledge, The Oxford Handbook of Global South Youth Studies offers a contribution from Southern scholars to remake Youth Studies from its current state, that universalises Northern perspectives, into a truly Global Youth Studies. Contributors from across various regions of the Global South, including from the Diaspora, Indigenous and Aboriginal communities, locate and define "the Global South", articulate the necessity of studying Southern lives to enrich, re-interpret, legitimate and offer symmetry to Youth Studies, and utilize and innovate Southern theory to do so. Eleven concepts are re-imagined and re-presented throughout the Handbook--personhood, intersectionality, violences, de- and post-coloniality, consciousness, precarity, fluid modernities, ontological insecurity, navigational capacities, collective agency and emancipation. The outcome is a series of everyday practices such as hustling, navigating, fixing, waiting, being on standby, silence, and life-writing, that demonstrate how youth living in adversity experiment with and push back against routine and conformity, and how research may support them in these endeavors and, simultaneously, redefine the relationships between knowledge, practice and politics-what the volume editors term "epistepraxis". The Handbook concludes with a nascent charter for a Global Youth Studies of benefit to the world, that no longer excludes, assumes or elides but rather includes new possibilities for representing youth, researching amongst them, and devising policies and interventions to better serve them. This volume is a critical addition to the field of Youth Studies and one that should be of interest to scholars, researchers, and students working in this area in both the Global North and South.