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The organocatalytic three-step total synthesis of (+)-frondosin B

โœ Scribed by Reiter, Maud; Torssell, Staffan; Lee, Sandra; MacMillan, David W. C.


Book ID
120448978
Publisher
The Royal Society of Chemistry
Year
2010
Tongue
English
Weight
347 KB
Volume
1
Category
Article
ISSN
2041-6520

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A total synthesis of the bioactive meroterpenoid natural products frondosin B and frondosin A (formal) from readily available cyclohexanone and gentisic aldehyde dimethyl ether, involving RCM as the key step to generate the bicyclic 6,7-fused core structure, is outlined.