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The Organic Cation Transporters rOCT1 and hOCT2 Are Inhibited by cGMP

✍ Scribed by E. Schlatter; V. Mönnich; I. Çetinkaya; T. Mehrens; G. Ciarimboli; J.R. Hirsch; C. Popp; H. Koepsell


Publisher
Springer
Year
2002
Tongue
English
Weight
181 KB
Volume
189
Category
Article
ISSN
0022-2631

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✍ Tomoe Fujita; Thomas J. Urban; Maya K. Leabman; Kazumi Fujita; Kathleen M. Giaco 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB

The human organic cation transporter 2 (OCT2, SLC22A2) is a multispecific transporter of organic cations, including many clinically used drugs. OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is considered a major