Oxybutynin and trospium are substrates of the human organic cation transporters
✍ Scribed by Birger Wenge; Joachim Geyer; Heinz Bönisch
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 239 KB
- Volume
- 383
- Category
- Article
- ISSN
- 0028-1298
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## Abstract The human organic cation transporter type 1 (hOCT1) is an important transport system for small organic cations in the liver. Organic cation transporters are regulated by different signaling pathways, but the regulation of hOCT1 has not yet been studied. In this work, we have for the fir
The human organic cation transporter 2 (OCT2, SLC22A2) is a multispecific transporter of organic cations, including many clinically used drugs. OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is considered a major